Information Letter of the European LeukemiaNet

Created by: Ihrig (ELIC) , generated 2006/02/14, last changed: 2013/02/27

The Information Letter is provided once per year before the annual Symposium of the European LeukemiaNet. It is a collaboration of the European Leukemia Information Center (ELIC), the Network Management Center (NMC), and the contributing authors. Topics of this online-publication medium range from basic research to clinical trials and the latest activities of the different work packages.


All ELN members are cordially invited to submit proposals of their field of research for prospective Information Letters to ELIC.

Current issue of the ELN Information Letter

Information Letter no. 9, February 2013 (4.0 MB)

for free download

WP5 – AML: Towards an integrated, risk adapted application of allogeneic stem cell transplantation for patients with AML in first complete remission
WP6 – ALL: Current approaches for antibody therapy in acute lymphoblastic leukemia (ALL)
WP11 – Cytogenetics: Quality assurance in leukemia cytogenetics by web-based processing of interlaboratory tests
WP4 – CML: European LeukemiaNet recommendations for the management and the treatment of chronic myeloid leukemia
WP15 – Supportive care: Recommendations on the management of respiratory viral infections
WP8 – MDS: Highlights from the MDS European LeukemiaNet WP 8
WP10 – Diagnostics: Highlights from the field of diagnosis
WP7 – CLL : European Research Initiative on CLL (ERIC) / ELN WP7
WP2 – ELIC: New European regulation on clinical trials on medicinal products for human use
EUTOS: Standardized definitions of molecular response in CML
ASH 2012: Clinical Results from Oral Presentations Summary of Selected Abstracts

Privious issues of the ELN Information Letter

Information Letter no. 8

Information Letter no. 8, February 2012 (2.3 MB)

for free download

WP8 – MDS: Highlights from the MDS field: European LeukemiaNet
WP8 – MDS: TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression
WP8 – MDS: Flow cytometry in myelodysplastic syndromes. Definitions, Clinical and Diagnostic Applications
WP4 – CML: Euro-SKI: Europe stop tyrosine kinase trial – the rational
WP5 – AML: The Role of Age versus Treatment Intensity in AML
WP9 – MPN: A novel murine model of MPN, generated by NF-E2 overexpression, displays spontaneous transformation to acute leukemia
WP6 – ALL: Recommendations of the European Working Group for Adult ALL
WP6 – ALL: Clinical Trials Directive – planned amendment by the EU
WP7 – CLL: European Research Initiative on CLL (ERIC)
ELN Foundation: Two Years of ELN Foundation
EUTOS for CML: Latest News about EUTOS

Information Letter no. 7

Information Letter no. 7, February 2011 (2.2 MB)

for free download

WP4 – CML: To stop treatment with Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia
WP9 – CMPD: SNP-Array Based Analysis in Myeloproliferative Neoplasms
WP11 – Cytogenetics: Whole genome sequencing
WP4 – CML: The EUTOS for CML Registry
WP5 – AML: Prospective comparison of different treatments with a common standard Treatment-Study by the German AML Intergroup
WP5 – AML: EBMT/ELN study for elderly patients with AML
WP5 – AML: TET2 Mutations in Acute Myeloid Leukemia (AML)
WP6 – ALL: Bispecific T-cell engaging (BiTE) Antibody Blinatumomab
WP9 – CMPD: Philadelphia-Negative Classical MPN: Critical concepts and Management Recommendations
WP10 – Diagnostic Platform: A European consenus report on blood cell identification
WP12 – MRD: A step in the right direction towards standardized reporting of minimal residual disease data
WP2 – ELIC: EU-directive on good clinical practice: Impact for independent research?
WP1 – NMC: ESF-ELN Research Networking Programms

Information Letter no. 6

Information Letter no. 6, February 2010 (2.7 MB)

for free download

WP4 – CML: Update of ELN treatment recommendations for chronic myeloid leukemia
EUTOS for CML: A successful collaboration
WP5 – AML: Is there a role for immunotherapy in maintaining complete remission in acute myeloid leukemia?
WP5 – AML: Developments in APL
WP5 – AML: Prospective Assessment of Outcome Determinants in AML: An ELN Pilot Project
WP14 – SCT: Main factors predicting outcome after hematopoietic stem cell transplantation
WP11 – Cytogenetics : Polymorphisms of DNA repair and detoxification genes in chronic lymphocytic leukemia
WP2 – ELIC: ELIC for impact assessment of EU-directive on good clinical practice
Network News: ELN Foundation, ALL: Acute lymphoblastic leukemia, Dates/Meetings, Ongoing studies of the European LeukemiaNet in the ELTR, Recommendations and Guidelines

Information Letter No.:	Content:
5^th Information Letter September 2008 Download PDF 1,4Mb	Project 4 CML: European Registry of chronic myelogenous leukemia patients in failure after imatinib therapy Project 5 AML: ChIP- chip microarrays to study the epigenome in leukemia Project 6 ALL: Important steps towards diagnostic standardization Project 7 CLL: New aspects of the updated guidelines for the diagnosis and treatment of chronic lymphocytic leukemia Project 13 Gene Profiling: Gene Analysis Platform (GAP) for ELN Network News: 1st ELN Workshop on international investigator-initiates-trials, ELTR News, A novel collaboration between academia and industry to improve treatment in CML, Dates & Meetings, Ongoing studies
4^th Information Letter October 2007 Download PDF 2Mb	Project 4 CML: The CML Group within the European Leukemia Network agreed on a long term Collaboration with Novartis Project 5 AML: The AML Intergroup: A Model of Cross-Trial Networking Project 6 ALL: Progress in Initiation of Paneuropean Trials Project 7 CLL: Finding Solutions for IGHV gene mutational Analysis in CLL Project 11 Cytogenetics: Correlation of whole Genome tiling Resolution Array CGH with Affymetrix Array Expression Analysis in AML/MDS Patients with 11q/MLL Amplification Project 2 ELIC: The German Leukemia and Lymphoma Patients’ Association and the European Cancer Patient Coalition Project 8 MDS: Development of a frailty Index for elderly Patients with MDS and AML by applying a multimodal geriatric Assessment including Quality of life Evaluation Project 6 ALL:Patient Information for ALL in Eight European Languages Project 15 Supportive Care: New Guidelines for Preventing and Treating infectious Diseases in leukemic Patients
3^rd Information Letter January 2007 Download PDF 1,2Mb	Project 4 CML: Recommendations for treatment of CML Projects 10 CLL & 13 Geneprofiling: Joint meeting at MLL, Munich Project 12 MRD: Development of real-time PCR Project 2 ELIC: European Leukemia Trial Registry Project 8 MDS: MDS Registry Project 9 CMPD: Consensus definition of resistance to Hydroxyurea in ET Project 11 Cytogenetics: t(16;21) (AML1-MTD16) with karyotype evolution identified in a de novo AML M1 patient Project 14 SCT:The unmet need for infrastructure in hematopoetic stem cell transplantation (HSCT)
2^nd Information Letter June 2006 Download PDF 4,4Mb	Project 6 ALL: Acute lymphoblastic leukemia Project 7 CLL: European Research Initiative on Cll (ERIC) Project 8 MDS: Actual state of WP 8 (MDS) Project 11 Cytogenetics: Analysis of AMl/MDS Patient with 11q/Mll Gene Amplification Project 14 Stem Cell Therapy: Stem Cell Transplantation Activity in europe 2004 Project 2 ELIC: Clinical Trials Registry Project 2 ELIC: Re-launch of the ELN-Website
1^st Information Letter August 2005 Download PDF 1,9Mb	Project 1 NMC: News from the Network Management Center Dates, Meetings Project 2 ELIC: Services provided by the European Leukemia Information Center Project 4 CML: Actual state of WP 4 (CML) Project 5 AML: Experiences from a Network of AML Trials using General Up-Front Randomization and a Common Standard Treatment Arm Project 11 Cytogenetics: Consensus protocols for cytogenetic diagnostics in leukemia Project 9 CMPD: Progress report Chronic Myeloproliferative Disorders Project 10 Diagnostic platform: European Immunophenotyping Panels Project 16 New Drugs:ELTRA: European Leukemia Treatment Research Association