Workpackage

Standards / SOP 's of Project 11: Cytogenetics

Created by: Hellenbrecht (ELIC) , generated 2006/03/14, last changed: 2010/02/22

Consensus protocols for chromosome banding and
FISH analyses

Consensus protocols of the ELN for cytogenetic analyses in leukemias have been published (Haferlach C, et al.: Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes. Genes, Chromosomes Cancer, 2007 May;46(5):494-9. link: PM:17311250)

Proposal for the rules and contents of
cytogenetic data collections

In treatment studies, cytogenetic data are used to classify patients according to distinct cytogenetic subgroups. The data records used to collect cytogenetic data may vary between different study groups and, thus, lead to inconsistencies of the contents of cytogenetic data. Such inconsistencies may hamper a detailed analysis of cytogenetic data in joint studies. Therefore, a proposal for the minimal data set and for the rules of data handling in cytogenetic studies of the ELN was drafted by WP11.

CytogeneticDataCollectionProposal.pdf

Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes
Genes Chromosomes Cancer. 2007 May;46(5):494-9.
The impact of cytogenetic characterization based on chromosome banding analyses and fluorescence in situ hybridization on clinical decision making has increased dramatically during recent years. Therefore, laboratory techniques have to be optimized to provide reliable results for optimal patient care. In addition, quick and correct results save time and money by preventing unnecessary additional diagnostics and suboptimal treatment approaches. It was our aim to present proposals for standardized protocols to improve the diagnosis, and hence the treatment outcome, of hematologic malignancies.

 

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